Allele-specific up-regulation of FGFR2 increases susceptibility to breast cancer.
The recent whole-genome scan for breast cancer has revealed the FGFR2 (fibroblast growth factor receptor 2) gene as a locus associated with a small, but highly significant, increase in barrel accessories the risk of developing breast cancer.Using fine-scale genetic mapping of the region, it has been possible to narrow the causative locus to a haplo